New paper – Reduced binding of apoE4 to complement factor H promotes amyloid-β oligomerization and neuroinflammation

New paper with our collaborator, Dr Karita Haapasalo at the University of Helsinki. In the paper, we elucidate the molecular mechanism of a genetic risk factor for Alzheimer’s disease. We show how the complement system interacts with apolipoprotein E (ApoE) to clear amyloid beta plaques and how this is impaired in the ApoE4 variant associated with late-onset Alzheimer’s. At Newcastle, we used single-molecule microscopy to visualise molecular ApoE-amyloid complexes directly and developed bespoke image analysis software to characterise these complexes in patient brain biopsy samples. (https://www.embopress.org/doi/full/10.15252/embr.202256467)